FBI Assistant Director Walter Skinner is the prime suspect in a homicide involving a woman he was with the night of her death. Mulder and Scully are all he has to prove his innocence, as superior officers try to shut him down and the only clue is a mysterious old woman.
就在這個(gè)節(jié)骨眼上，環(huán)游世界進(jìn)行著究神奇魔法動(dòng)物之行動(dòng)的法動(dòng)物學(xué)家紐特（埃迪·德梅恩 Eddie Redmayne 飾）抵達(dá)了紐約，他隨身攜儵魚的魔法提箱里，裝著幾十種他一營(yíng)救的魔法動(dòng)物們，而他一舉一動(dòng)，均處于隸屬于法部的前傲羅蒂娜（凱瑟·沃特森 Katherine Waterston 飾）的監(jiān)視之下。一場(chǎng)意外中，麻雞雅各士敬（丹·格勒 Dan Fogler 飾）誤拿了紐特的手提箱，并且放出了藏在箱子的魔法動(dòng)物，為此，紐特蒂娜、雅各布和蒂娜的妹奎妮（艾莉森·蘇朵兒 Alison Sudol 飾）不得不踏上了尋找魔動(dòng)物的旅途?