AP endonuclease

Apurinc/apyrimidinic endonuclease 1/redoxfactor 1 is a functional complexity of a biological macromolecule,with both endonuclease activation for apurinc/apyrimidinic sites and mediating ability of transcription factor.

脫嘌呤/脫嘧啶核酸內切酶1(APE1)是一個生物大分子功能復合體,既具有脫嘌呤/脫嘧啶位點(AP位點)核酸內切酶活性,又具調節轉錄因子的活性。

AIM:To investigate the correlation between p53 and apurinic/apyrimidinic endonuclease 1(APE1)gene expressions in epithelial ovarian carcinoma and their roles in the chemoresistance of ovarian carcinoma.

目的:探討脫嘌呤/脫嘧啶核酸內切酶(APE1)基因和P53在卵巢上皮性癌中的表達相關性,探討兩者與卵巢癌化療耐藥的相關性。

Objective To construct DNA damage and repair gene apurinic/apyrimidinic endonuclease (APE1) siRNA expression vector pSilence APE1 and investigate its inhibitory effect on the expression of APE1 in osteosarcoma cell HOS and 9901 in vitro.

目的構建DNA損傷修復基因脫嘌呤/脫嘧啶核酸內切酶APE1siRNA表達載體pSilenceAPE1,觀察其對骨肉瘤細胞HOS和9901APE1蛋白表達的抑制作用。

Objective To explore the relation between changes in apurinic/apyrimidinic endonuclease (APE1) gene expression and effects of melphalan on multiple myeloma (MM) cells.

目的探討脫嘌呤/脫嘧啶核酸內切酶(APE1)基因在多發性骨髓瘤(multiplemyeloma,MM)細胞中的表達變化及其與馬法蘭作用的關系。

Objective To investigate the role of apurimidinic endonuclease 1(APE1)in the carcinogenesis and progression of colorectal carcinoma(CRC).

目的探討DNA修復基因脫嘌呤/脫嘧啶核酸內切酶(apurinic/apyrimidinic endonuclease 1,APE1)在大腸癌發生、發展中的作用。

Objective To explore the relationship between genetic polymorphisms in apurinic/apyrimidinic endonuelease(APE1)and ADP ribosyltransferase(ADPRT) and individuals susceptibility to chronic benzene poi- son ing(BP).

目的探討脫嘌呤/脫嘧啶核酸內切酶(APEl)和腺苷酸二磷酸核糖基轉移酶(APDRT)的基因多態與慢性苯中毒易感性的關系。

Study on significance of single nucleotide polymorphisms in the redox domain of aprimidinic/apurinic endonuclease/redox factor-1 gene in Chinese sporadic colorectal cancer;

脫嘌呤/嘧啶核酸內切酶基因氧化還原功能區單核苷酸多態性在散發性大腸癌中存在意義的探討